Adrenal Cancer

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Causes and Risk Factors

The cause of adrenal cancer is unknown and most cases do not have identifiable risk factors. In some cases, heredity plays a role in the development of the disease. Li-Fraumeni syndrome and type 1 multiple endocrine neoplasia (MEN1) are genetic mutations in tumor suppressor genes that increase the risk for several types of cancer, including adrenal cancer.

Genetic testing may be recommended in families with a high incidence of suspected tumor suppressor gene mutation. Other familial syndromes associated with adrenal cancer include:

• Gardner syndrome
  
• Carney triad
  
• Cowden syndrome
  
• Familial polyposis
  
• Turcot syndrome
  

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